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Construction, expression and tumor targeting of a single-chain Fv against human colorectal carcinoma

AIM: A single-chain antibody fragment, ND-1scFv, against human colorectal carcinoma was constructed and expressed in E.coli, and its biodistribution and pharmacokinetic properties were studied in mice bearing tumor. METHODS: V(H) and V(L) genes were amplified from hybridoma cell IC-2, secreting mono...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Fang, Jin, Jin, Hong-Bin, Song, Jin-Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611438/
https://ncbi.nlm.nih.gov/pubmed/12679920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v9.i4.726
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