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Tumor Targeting by a Multivalent Single-Chain Fv (scFv) Anti-Lewis Y Antibody Construct

The use of single-chain variable fragment (scFv) constructs has been investigated in cancer radioimmunotherapy (RIT) and radioimmunodetection, as these molecules permit rapid tumor penetration and clearance from the serum relative to whole IgG. Multimerization of scFv constructs has demonstrated imp...

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Bibliografski detalji
Glavni autori: Kelly, Marcus P., Lee, F.-T., Tahtis, Kiki, Power, Barbara E., Smyth, Fiona E., Brechbiel, Martin W., Hudson, Peter J., Scott, Andrew M.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663784/
https://ncbi.nlm.nih.gov/pubmed/18771345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2007.0450
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