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IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB
Proinflammatory cytokines impact islet β-cell mass and function by altering the transcriptional activity within pancreatic β-cells, producing increases in intracellular nitric oxide abundance and the synthesis and secretion of immunomodulatory proteins such as chemokines. Herein, we report that IL-1...
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| Udgivet i: | Am J Physiol Endocrinol Metab |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609876/ https://ncbi.nlm.nih.gov/pubmed/26306596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00153.2015 |
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