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Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell lines
Synthesis and secretion of immunomodulatory proteins, such as cytokines and chemokines, controls the inflammatory response within pancreatic islets. When this inflammation does not resolve, destruction of pancreatic islet β-cells leads to diabetes mellitus. Production of the soluble mediators of inf...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157113/ https://ncbi.nlm.nih.gov/pubmed/24972324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2014.05.019 |
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