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Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell lines

Synthesis and secretion of immunomodulatory proteins, such as cytokines and chemokines, controls the inflammatory response within pancreatic islets. When this inflammation does not resolve, destruction of pancreatic islet β-cells leads to diabetes mellitus. Production of the soluble mediators of inf...

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Библиографические подробности
Главные авторы: Burke, Susan J., Lu, Danhong, Sparer, Tim E., Karlstad, Michael D., Collier, J. Jason
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157113/
https://ncbi.nlm.nih.gov/pubmed/24972324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2014.05.019
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