Regulation of iNOS Gene Transcription by IL-1β and IFN-γ Requires a Coactivator Exchange Mechanism

The proinflammatory cytokines IL-1β and IFN-γ decrease functional islet β-cell mass in part through the increased expression of specific genes, such as inducible nitric oxide synthase (iNOS). Dysregulated iNOS protein accumulation leads to overproduction of nitric oxide, which induces DNA damage, im...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Burke, Susan J., Updegraff, Barrett L., Bellich, Rachel M., Goff, Matthew R., Lu, Danhong, Minkin, Steven C., Karlstad, Michael D., Collier, J. Jason
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427878/
https://ncbi.nlm.nih.gov/pubmed/24014650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1159
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