Regulation of iNOS Gene Transcription by IL-1β and IFN-γ Requires a Coactivator Exchange Mechanism

The proinflammatory cytokines IL-1β and IFN-γ decrease functional islet β-cell mass in part through the increased expression of specific genes, such as inducible nitric oxide synthase (iNOS). Dysregulated iNOS protein accumulation leads to overproduction of nitric oxide, which induces DNA damage, im...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Endocrinol
Hauptverfasser: Burke, Susan J., Updegraff, Barrett L., Bellich, Rachel M., Goff, Matthew R., Lu, Danhong, Minkin, Steven C., Karlstad, Michael D., Collier, J. Jason
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2013
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427878/
https://ncbi.nlm.nih.gov/pubmed/24014650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1159
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge