Regulation of iNOS Gene Transcription by IL-1β and IFN-γ Requires a Coactivator Exchange Mechanism

The proinflammatory cytokines IL-1β and IFN-γ decrease functional islet β-cell mass in part through the increased expression of specific genes, such as inducible nitric oxide synthase (iNOS). Dysregulated iNOS protein accumulation leads to overproduction of nitric oxide, which induces DNA damage, im...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Endocrinol
Prif Awduron: Burke, Susan J., Updegraff, Barrett L., Bellich, Rachel M., Goff, Matthew R., Lu, Danhong, Minkin, Steven C., Karlstad, Michael D., Collier, J. Jason
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2013
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427878/
https://ncbi.nlm.nih.gov/pubmed/24014650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1159
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