Regulation of the CCL2 Gene in Pancreatic β-Cells by IL-1β and Glucocorticoids: Role of MKP-1

Release of pro-inflammatory cytokines from both resident and invading leukocytes within the pancreatic islets impacts the development of Type 1 diabetes mellitus. Synthesis and secretion of the chemokine CCL2 from pancreatic β-cells in response to pro-inflammatory signaling pathways influences immun...

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Main Authors: Burke, Susan J., Goff, Matthew R., Updegraff, Barrett L., Lu, Danhong, Brown, Patricia L., Minkin, Steven C., Biggerstaff, John P., Zhao, Ling, Karlstad, Michael D., Collier, J. Jason
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467264/
https://ncbi.nlm.nih.gov/pubmed/23056550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046986
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