CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells

Enhanced leukocytic infiltration into pancreatic islets contributes to inflammation-based diminutions in functional β-cell mass. Insulitis (aka islet inflammation), which can be present in both T1DM and T2DM, is one factor influencing pancreatic β-cell death and dysfunction. IL-1β, an inflammatory m...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Burke, Susan J., Karlstad, Michael D., Regal, Kellie M., Sparer, Tim E., Lu, Danhong, Elks, Carrie M., Grant, Ryan W., Stephens, Jacqueline M., Burk, David H., J. Jason, Collier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437873/
https://ncbi.nlm.nih.gov/pubmed/25882704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2015.03.007
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