IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB

Proinflammatory cytokines impact islet β-cell mass and function by altering the transcriptional activity within pancreatic β-cells, producing increases in intracellular nitric oxide abundance and the synthesis and secretion of immunomodulatory proteins such as chemokines. Herein, we report that IL-1...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Burke, Susan J., Stadler, Krisztian, Lu, Danhong, Gleason, Evanna, Han, Anna, Donohoe, Dallas R., Rogers, Richard C., Hermann, Gerlinda E., Karlstad, Michael D., Collier, J. Jason
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609876/
https://ncbi.nlm.nih.gov/pubmed/26306596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00153.2015
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