EGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling

Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines,...

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Publicado en:Mol Cell
Main Authors: Liu, Feng, Hon, Gary C., Villa, Genaro R., Turner, Kristen M., Ikegami, Shiro, Yang, Huijun, Ye, Zhen, Li, Bin, Kuan, Samantha, Lee, Ah Young, Zanca, Ciro, Wei, Bowen, Lucey, Greg, Jenkins, David, Zhang, Wei, Barr, Cathy L., Furnari, Frank B., Cloughesy, Timothy F., Yong, William H., Gahman, Timothy C., Shiau, Andrew K., Cavenee, Webster K., Ren, Bing, Mischel, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609298/
https://ncbi.nlm.nih.gov/pubmed/26455392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.002
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