Design, Synthesis and Pharmacological Characterization of a Fluorescent Agonist of the P2Y(14) Receptor

The P2Y(14)R is a G(i/o)-coupled receptor of the P2Y family of purinergic receptors that is activated by extracellular UDP and UDP-glucose (UDPG). In an earlier report we described a P2Y(14)R fluorescent probe, MRS4174, based on the potent and selective antagonist PPTN, a naphthoic acid derivative....

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Kiselev, Evgeny, Balasubramanian, Ramachandran, Uliassi, Elisa, Brown, Kyle A., Trujillo, Kevin, Katritch, Vsevolod, Hammes, Eva, Stevens, Raymond C., Harden, T. Kendall, Jacobson, Kenneth A.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607650/
https://ncbi.nlm.nih.gov/pubmed/26303895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.08.021
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