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Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase

PT70 is a diaryl ether inhibitor of InhA, the enoyl-ACP reductase in the Mycobacterium tuberculosis fatty acid biosynthesis pathway. It has a residence time of 24 min on the target, and also shows antibacterial activity in a mouse model of tuberculosis infection. Due to the interest in studying targ...

詳細記述

保存先:
書誌詳細
出版年:Bioorg Med Chem Lett
主要な著者: Wang, Hui, Liu, Li, Lu, Yang, Pan, Pan, Hooker, Jacob M., Fowler, Joanna S., Tonge, Peter J.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607644/
https://ncbi.nlm.nih.gov/pubmed/26227776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.07.019
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