Migration of PIP(2) lipids on voltage-gated potassium channel surface influences channel deactivation

Published studies of lipid-protein interactions have mainly focused on lipid binding to an individual site of the protein. Here, we show that a lipid can migrate between different binding sites in a protein and this migration modulates protein function. Voltage-gated potassium (Kv) channels have sev...

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Udgivet i:Sci Rep
Main Authors: Chen, Liping, Zhang, Qiansen, Qiu, Yunguang, Li, Zanyuan, Chen, Zhuxi, Jiang, Hualiang, Li, Yang, Yang, Huaiyu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606798/
https://ncbi.nlm.nih.gov/pubmed/26469389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15079
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