Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors

PURPOSE: Wee1 tyrosine kinase phosphorylates and inactivates cyclin-dependent kinase (Cdk) 1/2 in response to DNA damage. AZD1775 is a first-in-class inhibitor of Wee1 kinase with single-agent antitumor activity in preclinical models. We conducted a phase I study of single-agent AZD1775 in adult pat...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Do, Khanh, Wilsker, Deborah, Ji, Jiuping, Zlott, Jennifer, Freshwater, Tomoko, Kinders, Robert J., Collins, Jerry, Chen, Alice P., Doroshow, James H., Kummar, Shivaani
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606059/
https://ncbi.nlm.nih.gov/pubmed/25964244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.60.4009
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