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Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity
[Image: see text] Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Crystal structures of the ectodomain of...
שמור ב:
| הוצא לאור ב: | J Med Chem |
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| Main Authors: | , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American
Chemical
Society
2015
|
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601487/ https://ncbi.nlm.nih.gov/pubmed/26351878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01087 |
| תגים: |
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