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Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Lipopolysaccharide (LPS), also known as endotoxin, activates the innate immune response through toll-like receptor 4 (TLR4) and its coreceptor, MD-2. MD-2 has a unique hydrophobic cavity that directly binds to lipid A, the active center of LPS. Tetraacylated lipid IVa, a synthetic lipid A precursor,...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358893/ https://ncbi.nlm.nih.gov/pubmed/22532668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201193109 |
| Etiketak: |
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