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Small-molecule TLR8 antagonists via structure-based rational design
Rational design of drug-like small-molecule ligands based on structural information of proteins remains a significant challenge in chemical biology. In particular, designs targeting protein-protein interfaces have met little success given the dynamic nature of the protein surfaces. Herein, we utiliz...
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| Publicado no: | Cell Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6195466/ https://ncbi.nlm.nih.gov/pubmed/30100350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.07.004 |
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