Small-molecule inhibition of TLR8 through stabilization of its resting state

Endosomal Toll-like receptors (TLR3/7/8/9) are highly analogous sensors for various viral or bacterial RNA/DNA molecular patterns. Nonetheless, few small-molecules can selectively modulate these TLRs. In this manuscript, we identified the first human TLR8-specific small-molecule antagonists via a no...

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Udgivet i:Nat Chem Biol
Main Authors: Zhang, Shuting, Hu, Zhenyi, Tanji, Hiromi, Jiang, Shuangshuang, Das, Nabanita, Li, Jing, Sakaniwa, Kentaro, Jin, Jin, Bian, Yanyan, Ohto, Umeharu, Shimizu, Toshiyuki, Yin, Hang
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726935/
https://ncbi.nlm.nih.gov/pubmed/29155428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2518
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