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Small-molecule inhibition of TLR8 through stabilization of its resting state
Endosomal Toll-like receptors (TLR3/7/8/9) are highly analogous sensors for various viral or bacterial RNA/DNA molecular patterns. Nonetheless, few small-molecules can selectively modulate these TLRs. In this manuscript, we identified the first human TLR8-specific small-molecule antagonists via a no...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726935/ https://ncbi.nlm.nih.gov/pubmed/29155428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2518 |
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