Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

[Image: see text] Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Crystal structures of the ectodomain of...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Beesu, Mallesh, Caruso, Giuseppe, Salyer, Alex C. D., Khetani, Karishma K., Sil, Diptesh, Weerasinghe, Mihiri, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601487/
https://ncbi.nlm.nih.gov/pubmed/26351878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01087
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