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Histone mono-ubiquitination by a Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback

Circadian rhythms in mammals are driven by a feedback loop in which the transcription factor Clock–Bmal1 activates expression of Per and Cry proteins, which together form a large nuclear complex (Per complex) that represses Clock–Bmal1 activity. We found that mouse Clock–Bmal1 recruits the Ddb1–Cull...

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發表在:Nat Struct Mol Biol
Main Authors: Tamayo, Alfred G., Duong, Hao A., Robles, Maria S., Mann, Matthias, Weitz, Charles J.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600324/
https://ncbi.nlm.nih.gov/pubmed/26323038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3076
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