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O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination
Circadian clocks are coupled to metabolic oscillations through nutrient-sensing pathways. Nutrient flux into the hexosamine biosynthesis pathway triggers covalent protein modification by O-linked β-D-N-acetylglucosamine (O-GlcNAc). Here we show that the hexosamine/O-GlcNAc pathway modulates peripher...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647362/ https://ncbi.nlm.nih.gov/pubmed/23395176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.12.015 |
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