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A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery
Circadian clocks in mammals are built on a negative feedback loop in which the heterodimeric transcription factor circadian locomotor output cycles kaput (CLOCK)-brain, muscle Arnt-like 1 (BMAL1) drives the expression of its own inhibitors, the PERIOD and CRYPTOCHROME proteins. Reactivation of CLOCK...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791755/ https://ncbi.nlm.nih.gov/pubmed/24043798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305980110 |
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