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A molecular mechanism for circadian clock negative feedback
Circadian rhythms in mammals are generated by a feedback loop in which the three PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the CLOCK-BMAL1 dimer, repressing their own expression. Although fundamental, the mechanism of negative feedback in the mammalian...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859310/ https://ncbi.nlm.nih.gov/pubmed/21680841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1196766 |
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