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Strategies for imputing and analyzing rare variants in association studies

Rare genetic variants may be responsible for a significant amount of the uncharacterized genetic risk underlying many diseases. An efficient approach to characterizing the disease burden of rare variants may be to impute them into existing large datasets. It is well-known that the ability to impute...

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Udgivet i:Trends Genet
Main Authors: Hoffmann, Thomas J., Witte, John S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600126/
https://ncbi.nlm.nih.gov/pubmed/26450338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2015.07.006
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