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Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates

Rare variants may help to explain some of the missing heritability of complex diseases. Technological advances in next-generation sequencing give us the opportunity to test this hypothesis. We propose two new methods (one for case-control studies and one for family-based studies) that combine aggreg...

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Autores principales: Kazma, Rémi, Hoffmann, Thomas J, Witte, John S
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287864/
https://ncbi.nlm.nih.gov/pubmed/22373382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-5-S9-S29
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