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On the Substructure Controls in Rare Variant Analysis --- Principal Components or Variance Components?
Recent studies showed that the impact of population substructure (PS) can be more complex on rare variant tests and that similarity-based collapsing tests (e.g., SKAT) may suffer more severe impact by PS than burden-based tests. Given that different PS correction methods have not been comprehensivel...
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| Gepubliceerd in: | Genet Epidemiol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851819/ https://ncbi.nlm.nih.gov/pubmed/29280188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22102 |
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