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Imputation of rare variants in next generation association studies

The role of rare variants has become a focus in the search for association with complex traits. Imputation is a powerful and cost-efficient tool to access variants that have not been directly typed, but there are several challenges when imputing rare variants, most notably reference panel selection....

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Bibliografiske detaljer
Main Authors: Asimit, Jennifer L, Zeggini, Eleftheria
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954458/
https://ncbi.nlm.nih.gov/pubmed/23594497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000345602
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