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Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na(+) Channel Knuckle Domain
The extracellular regions of epithelial Na(+) channel subunits are highly ordered structures composed of domains formed by α helices and β strands. Deletion of the peripheral knuckle domain of the α subunit in the αβγ trimer results in channel activation, reflecting an increase in channel open proba...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599017/ https://ncbi.nlm.nih.gov/pubmed/26306034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665398 |
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