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Probing the Structural Basis of Zn(2+) Regulation of the Epithelial Na(+) Channel

Extracellular Zn(2+) activates the epithelial Na(+) channel (ENaC) by relieving Na(+) self-inhibition. However, a biphasic Zn(2+) dose response was observed, suggesting that Zn(2+) has dual effects on the channel (i.e. activating and inhibitory). To investigate the structural basis for this biphasic...

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Autors principals: Chen, Jingxin, Winarski, Katie L., Myerburg, Mike M., Pitt, Bruce R., Sheng, Shaohu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471688/
https://ncbi.nlm.nih.gov/pubmed/22930753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394734
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