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Analyses of epithelial Na(+) channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating

Epithelial Na(+) channel (ENaC)-mediated Na(+) transport has a key role in the regulation of extracellular fluid volume, blood pressure, and extracellular [K(+)]. Among the thousands of human ENaC variants, only a few exist whose functional consequences have been experimentally tested. Here, we used...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Chen, Jingxin, Shi, Shujie, Sheng, Shaohu, Kleyman, Thomas R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851303/
https://ncbi.nlm.nih.gov/pubmed/31551351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010001
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