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Analyses of epithelial Na(+) channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating
Epithelial Na(+) channel (ENaC)-mediated Na(+) transport has a key role in the regulation of extracellular fluid volume, blood pressure, and extracellular [K(+)]. Among the thousands of human ENaC variants, only a few exist whose functional consequences have been experimentally tested. Here, we used...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6851303/ https://ncbi.nlm.nih.gov/pubmed/31551351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010001 |
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