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Extracellular Allosteric Regulatory Subdomain within the γ Subunit of the Epithelial Na(+) Channel
The activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) self-inhibition, a down-regulation of the open probability of ENaC by extracellular Na(+). A His residue within the extracellular domain of γENaC (γHis(239)) was found to have a critical role in Na(+) self-inhibition. We inves...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924010/ https://ncbi.nlm.nih.gov/pubmed/20587418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149963 |
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