Thumb domains of the three epithelial Na(+) channel subunits have distinct functions

The epithelial Na(+) channel (ENaC) possesses a large extracellular domain formed by a β-strand core enclosed by three peripheral α-helical subdomains, which have been dubbed thumb, finger, and knuckle. Here we asked whether the ENaC thumb domains play specific roles in channel function. To this end...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Sheng, Shaohu, Chen, Jingxin, Mukherjee, Anindit, Yates, Megan E., Buck, Teresa M., Brodsky, Jeffrey L., Tolino, Michael A., Hughey, Rebecca P., Kleyman, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231141/
https://ncbi.nlm.nih.gov/pubmed/30228189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003618
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