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Thumb domains of the three epithelial Na(+) channel subunits have distinct functions
The epithelial Na(+) channel (ENaC) possesses a large extracellular domain formed by a β-strand core enclosed by three peripheral α-helical subdomains, which have been dubbed thumb, finger, and knuckle. Here we asked whether the ENaC thumb domains play specific roles in channel function. To this end...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6231141/ https://ncbi.nlm.nih.gov/pubmed/30228189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003618 |
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