Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death

We previously reported that the skeletal muscle-specific overexpression of Fyn in mice resulted in a severe muscle wasting phenotype despite the activation of mTORC1 signaling. To investigate the bases for the loss of muscle fiber mass, we examined the relationship between Fyn activation of mTORC1,...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Yichen, Yamada, Eijiro, Zong, Haihong, Pessin, Jeffrey E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598989/
https://ncbi.nlm.nih.gov/pubmed/26306048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687020
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