Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation

Pompe disease is due to a deficiency in acid-α-glucosidase (GAA) and results in debilitating skeletal muscle wasting, characterized by the accumulation of glycogen and autophagic vesicles. Given the role of lysosomes as a platform for mTORC1 activation, we examined mTORC1 activity in models of Pompe...

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Udgivet i:Am J Physiol Regul Integr Comp Physiol
Main Authors: Shemesh, Adi, Wang, Yichen, Yang, Yingjuan, Yang, Gong-She, Johnson, Danielle E., Backer, Jonathan M., Pessin, Jeffrey E., Zong, Haihong
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Physical Activity and Inactivity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233288/
https://ncbi.nlm.nih.gov/pubmed/25231351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00212.2014
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