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Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation
Pompe disease is due to a deficiency in acid-α-glucosidase (GAA) and results in debilitating skeletal muscle wasting, characterized by the accumulation of glycogen and autophagic vesicles. Given the role of lysosomes as a platform for mTORC1 activation, we examined mTORC1 activity in models of Pompe...
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| 發表在: | Am J Physiol Regul Integr Comp Physiol |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Physiological Society
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233288/ https://ncbi.nlm.nih.gov/pubmed/25231351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00212.2014 |
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