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Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death

We previously reported that the skeletal muscle-specific overexpression of Fyn in mice resulted in a severe muscle wasting phenotype despite the activation of mTORC1 signaling. To investigate the bases for the loss of muscle fiber mass, we examined the relationship between Fyn activation of mTORC1,...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Wang, Yichen, Yamada, Eijiro, Zong, Haihong, Pessin, Jeffrey E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598989/
https://ncbi.nlm.nih.gov/pubmed/26306048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687020
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