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Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis
KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Pub. Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598737/ https://ncbi.nlm.nih.gov/pubmed/26420673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9419 |
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