A carregar...
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis
KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces...
Na minha lista:
| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598737/ https://ncbi.nlm.nih.gov/pubmed/26420673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9419 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|