Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces...

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Udgivet i:Nat Commun
Main Authors: Hu, Dong, Gur, Mert, Zhou, Zhuan, Gamper, Armin, Hung, Mien-Chie, Fujita, Naoya, Lan, Li, Bahar, Ivet, Wan, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598737/
https://ncbi.nlm.nih.gov/pubmed/26420673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9419
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