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A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy
BACKGROUND: Triple negative breast cancers (TNBCs) have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The malignant and invasive feature of TNBCs is correlated with its high cancer stem cell population. Recent results from us and others have unveiled an oncogenic ro...
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| Publicat a: | EBioMedicine |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6604046/ https://ncbi.nlm.nih.gov/pubmed/31101597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.011 |
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