A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

BACKGROUND: Triple negative breast cancers (TNBCs) have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The malignant and invasive feature of TNBCs is correlated with its high cancer stem cell population. Recent results from us and others have unveiled an oncogenic ro...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Zhou, Zhuan, Feng, Zhiwei, Hu, Dong, Yang, Peng, Gur, Mert, Bahar, Ivet, Cristofanilli, Massimo, Gradishar, William J., Xie, Xiang-qun, Wan, Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604046/
https://ncbi.nlm.nih.gov/pubmed/31101597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.011
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