New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly(ADP‐ribosyl)ation (PARylation). We revealed the subcellular compartmentation for KLF4 is orchestrated by PARP1‐mediated PARylation....

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Zhou, Zhuan, Huang, Furong, Shrivastava, Indira, Zhu, Rui, Luo, Aiping, Hottiger, Michael, Bahar, Ivet, Liu, Zhihua, Cristofanilli, Massimo, Wan, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721363/
https://ncbi.nlm.nih.gov/pubmed/33231937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012391
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