A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

BACKGROUND: Triple negative breast cancers (TNBCs) have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The malignant and invasive feature of TNBCs is correlated with its high cancer stem cell population. Recent results from us and others have unveiled an oncogenic ro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EBioMedicine
Egile Nagusiak: Zhou, Zhuan, Feng, Zhiwei, Hu, Dong, Yang, Peng, Gur, Mert, Bahar, Ivet, Cristofanilli, Massimo, Gradishar, William J., Xie, Xiang-qun, Wan, Yong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2019
Gaiak:
Research paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604046/
https://ncbi.nlm.nih.gov/pubmed/31101597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.011
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