Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization

Platelet aggregation at sites of vascular injury is not only essential for hemostasis, but may also cause acute ischemic disease states such as myocardial infarction or stroke. The hemi-immunoreceptor tyrosine-based activation motif–containing C-type lectinlike receptor 2 (CLEC-2) mediates powerful...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Lorenz, Viola, Stegner, David, Stritt, Simon, Vögtle, Timo, Kiefer, Friedemann, Witke, Walter, Schymeinsky, Jürgen, Watson, Steve P., Walzog, Barbara, Nieswandt, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598192/
https://ncbi.nlm.nih.gov/pubmed/25795918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-611905
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