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Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development
Mice with a constitutive or platelet-specific deletion of the C-type-lectin-like receptor (CLEC-2) exhibit hemorrhaging in the brain at mid-gestation. We sought to investigate the basis of this defect, hypothesizing that it is mediated by the loss of CLEC-2 activation by its endogenous ligand, podop...
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| Publicado no: | Blood |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4463737/ https://ncbi.nlm.nih.gov/pubmed/25908104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-603803 |
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