The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Platelets play a critical role in vascular inflammation through the podoplanin and collagen/fibrin receptors, C-type-lectin-like-2 (CLEC-2) and glycoprotein VI (GPVI), respectively. Both receptors regulate endothelial permeability and prevent peri-vascular bleeding in inflammation. Here we show that...

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Foilsithe in:Nat Commun
Main Authors: Rayes, Julie, Lax, Siân, Wichaiyo, Surasak, Watson, Stephanie K., Di, Ying, Lombard, Stephanie, Grygielska, Beata, Smith, Stuart W., Skordilis, Kassiani, Watson, Steve P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740111/
https://ncbi.nlm.nih.gov/pubmed/29269852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02402-6
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