Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

Mice with a constitutive or platelet-specific deletion of the C-type-lectin-like receptor (CLEC-2) exhibit hemorrhaging in the brain at mid-gestation. We sought to investigate the basis of this defect, hypothesizing that it is mediated by the loss of CLEC-2 activation by its endogenous ligand, podop...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Lowe, Kate L., Finney, Brenda A., Deppermann, Carsten, Hägerling, René, Gazit, Salomé L., Frampton, Jon, Buckley, Christopher, Camerer, Eric, Nieswandt, Bernhard, Kiefer, Friedemann, Watson, Steve P.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2015
Sujets:
Platelets and Thrombopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463737/
https://ncbi.nlm.nih.gov/pubmed/25908104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-603803
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