CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation, and perinatal lethality. Furthermore, we find that condi...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Finney, Brenda A., Schweighoffer, Edina, Navarro-Núñez, Leyre, Bénézech, Cecile, Barone, Francesca, Hughes, Craig E., Langan, Stacey A., Lowe, Kate L., Pollitt, Alice Y., Mourao-Sa, Diego, Sheardown, Steve, Nash, Gerard B., Smithers, Nicholas, Reis e Sousa, Caetano, Tybulewicz, Victor L. J., Watson, Steve P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2012
Gaiak:
Platelets and Thrombopoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351942/
https://ncbi.nlm.nih.gov/pubmed/22186994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-380709
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