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The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets
We have used a novel knockin mouse to investigate the effect of disruption of phosphotyrosine binding of the N-terminal SH2 domain of Syk on platelet activation by GPVI, CLEC-2, and integrin αIIbβ3. The Syk(R41Afl/fl) mouse was crossed to a PF4-Cre(+) mouse to induce expression of the Syk mutant in...
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| Publicado no: | Blood |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281823/ https://ncbi.nlm.nih.gov/pubmed/25352128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-579375 |
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