Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization

Platelet aggregation at sites of vascular injury is not only essential for hemostasis, but may also cause acute ischemic disease states such as myocardial infarction or stroke. The hemi-immunoreceptor tyrosine-based activation motif–containing C-type lectinlike receptor 2 (CLEC-2) mediates powerful...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Lorenz, Viola, Stegner, David, Stritt, Simon, Vögtle, Timo, Kiefer, Friedemann, Witke, Walter, Schymeinsky, Jürgen, Watson, Steve P., Walzog, Barbara, Nieswandt, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598192/
https://ncbi.nlm.nih.gov/pubmed/25795918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-611905
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