Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization

Platelet aggregation at sites of vascular injury is not only essential for hemostasis, but may also cause acute ischemic disease states such as myocardial infarction or stroke. The hemi-immunoreceptor tyrosine-based activation motif–containing C-type lectinlike receptor 2 (CLEC-2) mediates powerful...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Lorenz, Viola, Stegner, David, Stritt, Simon, Vögtle, Timo, Kiefer, Friedemann, Witke, Walter, Schymeinsky, Jürgen, Watson, Steve P., Walzog, Barbara, Nieswandt, Bernhard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2015
Aiheet:
Thrombosis and Hemostasis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598192/
https://ncbi.nlm.nih.gov/pubmed/25795918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-611905
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