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CLEC-2 activates Syk through dimerisation
The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including PLCγ2. Signalling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequen...
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| Vydáno v: | Blood |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4361903/ https://ncbi.nlm.nih.gov/pubmed/20154219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-237834 |
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