CLEC-2 activates Syk through dimerisation

The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including PLCγ2. Signalling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequen...

Full description

Saved in:
Bibliographic Details
Published in:Blood
Main Authors: Hughes, Craig E., Pollitt, Alice Y., Mori, Jun, Eble, Johannes A., Tomlinson, Michael G., Hartwig, John H., O’Callaghan, Christopher A., Fütterer, Klaus, Watson, Steve P.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361903/
https://ncbi.nlm.nih.gov/pubmed/20154219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-237834
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items